MISSION
Children are not just small adults. Their bodies and health challenges are unique, including the pathogenesis of autoimmune diseases. Unlike adults, children's immune systems are still developing, which can lead to distinctive patterns in how rheumatic diseases manifest and progress in them.Our mission is not only to unravel the mysteries of pediatric autoimmunity but also to translate our findings into better, child-specific treatments.
RESEARCH
Intraepithelial lymphocytes (IELs) are a largest population of tissue-resident lymphocytes residing within the intestinal epithelium, vital for infection defense and tissue repair. Proper regulation of IEL activation is critical, as overactivation can lead to tissue damage.
Our research focuses on understanding the transcriptional and epigenetic frameworks that govern IEL functions and development. We strive to uncover how these regulatory mechanisms operate to keep IEL activity in check, aiming to impact the treatment of autoimmune and inflammatory diseases significantly.
MEMBERS
Kentaro Yomogida, MD
Assistant Professor, Department of Pediatrics
Rose Fierkens
Professional Research Assistant
PUBLICATIONS
The transcription factor Aiolos restrains activation of intestinal intraepithelial lymphocytes.
Yomogida K, Trsan T, Sudan R, Rodrigues P, Ulezko Antonova A, Ingle H, Di Luccia B, Collins P, Cella M, Gilfillan S, Baldridge M, Oltz E, Colonna M. Nature Immunology DOI: 10.1038/s41590-023-01693-w. PMID: 38049581.
The aryl hydrocarbon receptor instructs the immunomodulatory profile of a subset of Clec4a4 + eosinophils unique to the small intestine.
Wang WL, Kasamatsu J, Joshita S, Gilfillan S, Di Luccia B, Panda SK, Kim DH, Desai P, Bando JK, Huang S, Yomogida K, Hoshino H, Fukushima M, Jacobsen E, Van Dyken S, Ruedl C, Cella M, Colonna M. Proceedings of the National Academy of Sciences. 2022 Jun 7;119(23):e2204557119. DOI: 10.1073/pnas.2204557119. PMID: 35653568.
Hobit confers tissue dependent programs to type 1 innate lymphoid cells.
Yomogida K, Bigley T, Trsan T, Gilfillan S, Cella M, Yokoyama W, Egawa T, Colonna M. Proceedings of the National Academy of Sciences. 2021 Dec 14;118(50):e2117965118. DOI: 10.1073/pnas.2117965118. PMID: 34880136.
Subsets of ILC3-ILC1-like cells generate a diversity spectrum of ILCs in human mucosal tissues.
Cella M, Gamini R, Sécca C, Collins P, Zhao S, Peng V, Robinette M, Schettini J, Zaitsev K, Gordon W, Bando J, Yomogida K, Cortez V, Fronick C, Fulton R, Lin L, Gilfillan S, Flavell R, Shan L, Artyomov M, Bowman M, Oltz E, Jelinsky S, Colonna M. Nature immunology. 2019 Aug;20(8):980-991. DOI: 10.1038/s41590-019-0425-y. PMID: 31209406.
CD4 aptamer-RORgt shRNA Chimera Inhibits IL-17 Synthesis by Human CD4+ T cells.
Song P, Chou Y, Zhang X, Meza-Romero R, Yomogida K, Benedek G, Chu CQ. Biochemical and Biophysical Research Communications. 2014 Oct 3;452 (4): 1040-5. DOI: 10.1016/j.bbrc.2014.09.037. PMID: 25241192.
Superantigens induce IL-17 production from polarized Th1 clones.
Yomogida K, Chou Y and Chu CQ. Cytokine. 2013 Jul;63(1):6-9
Cell penetrating recombinant Foxp3 protein enhances Treg function and ameliorates arthritis.
Yomogida K, Wu S, Baravati B, Avendano C, Caldwell T, Maniaci B, Zhu Y, Chu CQ. Biochemical and Biophysical Research Communications. 2013 May 3;434 (2) 263-267. DOI: 10.1016/j.bbrc.2013.02.114. PMID: 23541572.
Efficacy of Phosphodiesterase 5 inhibitor on distant burn-induced muscle autophagy, microcirculation and, survival rate.
Hosokawa S, Nagashima M, Maeyama Y, Koseki H, Yomogida K, Mehr C, Rutledge M, Greenfeld H, Kaneki M, Tompkins R, Martyn J, Yasuhara S. American Journal of Physiology - Endocrinology and Metabolism 2013 May 1;304(9):E922-33. DOI: 10.1152/ajpendo.00078.2013. PMID: 23512808
Streptavidin suppresses T cell activation by inhibiting expression of interleukin 2 and interleukin 2 receptor.
Yomogida K, Chou Y, Pang J, Baravati B, Maniaci B, Wu S, Zhu Y, Chu CQ. Cytokine. 2012;58(3):431-6. DOI: 10.1016/j.cyto.2012.02.007. PMID: 22410319.
Identification of mouse C-terminally- and N-terminally-truncated estrogen receptor alpha variants.
Ishii H, Shoda Y, Yomogida K, Hamada T, Sakuma Y. The Journal of Steroid Biochemistry and Molecular Biology, 2011 Mar;124(1-2):38-46. DOI: 10.1016/j.jsbmb.2011.01.003. PMID: 21251978
OPEN POSITIONS
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Yomogida lab is seeking graduate students, technicians and post docs who are looking for the opportunity to advance their career. Please contact Kentaro Yomogida (kentaro.yomogida@cuanschutz.edu) for more details.